Working in veterinary shelter medicine can be a deeply rewarding profession, as it allows healthcare professionals to make a positive impact on the lives of animals in need. However, it also comes with its unique challenges, including the risk of compassion fatigue. This phenomenon refers to the emotional exhaustion and gradual decline in empathy experienced by individuals exposed to the suffering and distress of others, commonly seen in caregivers and helping professionals, including veterinarians and shelter workers. Compassion fatigue can have a significant impact on the mental, emotional, and physical well-being of veterinary professionals, potentially leading to burnout and decreased job satisfaction. Let's explore this issue further, backed by statistics, and learn effective ways to prevent and manage compassion fatigue.